TABLE 1.

Tumor incidence in Zhx2 ^KO mice and Zhx2 ^wt littermates after DEN exposure

	Treatment	Tumor incidence
		Male		Female
		Zhx2 wt	Zhx2 KO	Zhx2 wt	Zhx2 KO
9 months	PBS	0% (0 of 15)	0% (0 of 9)	0% (0 of 14)	0% (0 of 10)
	DEN	100% (14 of 14)	0% (0 of 11)	25% (3 of 12)	0% (0 of 10)
10 months	PBS	0% (0 of 10)	0% (0 of 11)	0% (0 of 9)	0% (0 of 10)
	DEN	100% (10 of 10)	0% (0 of 11)	36% (4 of 11)	0% (0 of 11)

Note: Zhx2 ^KO mice and Zhx2 ^wt littermates were given a single intraperitoneal injection of DEN (10 mg/kg; Sigma‐Aldrich) or vehicle (PBS) at 14 days of age. Livers were removed and tumor loads were examined 9 or 10 months after DEN exposure. Number of mice with tumor/cohort in parentheses.