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. 2022 Oct 20;6(12):3311–3323. doi: 10.1002/hep4.2082

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© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Global DNA methylation and histone signatures in plasma of pediatric patients with nonalcoholic fatty liver disease (NAFLD). (A) Percentage of cell‐free DNA (cfDNA) methylation in NAFLD (red) and control (green) patients. ***p < 0.001 vs. controls. (B) Box plots of the standardized individual histones expression in NAFLD (red) and controls (green); outliers were removed; the horizontal bars represent the medians and the whiskers. *p < 0.05 vs. controls. (C) Percentage of cfDNA methylation in patients with nonalcoholic steatohepatitis (NASH) NAFLD (red) and no NASH (yellow). ***p < 0.001 vs. controls. (D) Box plots of the standardized histones expression in patients with NASH (red) and no NASH (yellow); outliers were removed; the horizontal bars represent the medians and the whiskers.