Table 1.

Psychopharmacologic Management of Bipolar Disorder by Phase of Illness

	Mania	Depression	Maintenance
First-line treatment	Lithium* Quetiapine* Risperidone, Paliperidone* Aripiprazole* Asenapine Divalproex Cariprazine	Quetiapine* Lurasidone* Lithium* Lamotrigine	Lithium* Quetiapine* Lamotrigine* Divalproex Asenapine Aripiprazole
Second-line treatment	Olanzapine Carbamazepine Ziprasidone Haloperidol ECT	Divalproex Cariprazine ECT	Olanzapine Risperidone Carbamazepine Paliperidone

Notes: *Our first-line recommendations based on evidence supporting their use, CANMAT guideline recommendations, and/or FDA approved indications.