Table 1.

Potential Genetic Contributors to AD

Skin Barrier
	Epidermal differentiation complex	FLG, FLG2, HRNR, LCE2C, LCE4A, LCE5A, RPTN, S100A3, S100A7, S100A8, S100A16, SPRR3, SPRR4, TCHH, TCHHL1, CLDN1, Tmem79/matt, LELP1
	SP and SP inhibition	SERPINB7, KLK7
	Desmosome component	DSC1
	Epigenetics	KIF3A methylation, PPARδ upregulation, EMSY upregulation
Immune System
	Innate immunity	TLR2, TLR4, TLR9, NOD1, NOD2, DEFβ1, IFNγ, IFNγR, IRF2, SIDT2, RBBP8NL
	Cytokine-related	IL4/4R, IL5, IL7R, IL9, IL10, IL12, IL13, IL18, IL31, TSLP, STAT6
	Antigen receptor signaling	CARD14, LRRC32
	IgE-related	FcεRIβ, ADAMTSL4
	Leukotriene-related	CYSLTR1
	Epigenetics	AHR upregulation, reduced IL13 methylation, reduced AcH3K9 acetylation

Note: Gene names are italicized.