Table 2.

Genetic Disorders with AD-Like Lesions and Their Implicated Genes

Hyper-IgE syndrome
	Cytokine-related	STAT3
	Actin polymerization	DOCK8
CARMIL2 deficiency
	Antigen receptor signaling, actin polymerization	CARMIL2
Omenn syndrome
	Antigen receptor signaling	RAG1, RAG2
Netherton syndrome
	SP inhibition	SPINK5
Wiskott-Aldrich syndrome
	Actin polymerization	WAS
ADA-SCID
	Antigen receptor signaling	ADA
IPEX syndrome
	Cytokine-related	FOXP3
CADINS disease
	Antigen receptor signaling	CARD11
Congenital disorders of glycosylation
	Cellular metabolism	PGM3
Prolidase deficiency
	Collagen metabolism	PEPD
SAM syndrome
	Desmosome components	DSG1, DSP
GHI syndrome with immunodeficiency
	Cytokine-related	STAT5B
Novel autosomal dominant allergic disorder
	Cytokine-related	STAT6

Note: Gene names are italicized.