Table 3.

Suggested Surgical Prophylaxis in Adults with Acquired haemophilia⁹⁴

Dental Extractions

APCC, 50 to 75 IU/kg/12 h, 2 to 3 doses, starting just before surgery rFVIIa, 90 to 120 μg/kg/2h, 3 to 4 doses, starting just before surgery minor surgery

Minor Surgery

APCC, 50 to 100 IU/kg/8–12 h, without exceeding 200 IU/kg/day. Start just before surgery. Treatment 3–7 days depending on evolution rFVIIa, 90 to 120 μg/kg/2–3 hours for 24 hours. Start just before surgery. Repeat dose every 4 to 6 hours for 3 to 7 days depending on evolution

Major Surgery

APCC, 75 to 100 IU/kg/8–12 hours on days 1 to 6, then every 12 hours on days 7 to 15, not to exceed 200 IU/kg/day. Start just before surgery. Adjust according to evolution rFVIIa, 90 to 120 μg/kg/2 hours for 24 hours, every 2 to 3 hours on day 2, every 4 hours on days 3 to 5, every 6 hours on days 6 to 15. Start just before surgery. Adjust according to evolution