Table 2.
Characteristics and outcomes of high-risk evolvers
| Monosomy 7 | Other chromosome 7 (n=5) | Other | P value | |
|---|---|---|---|---|
| (n=39) | (n=15) | |||
| Laboratory values at time of high-risk evolution (median) | ||||
| ANC (×109/l) | 0.64 (0–3.29) | 1.77 (0.92–2.29) | 1.76 (0.26–32.1) | 0.002 |
| ARC (×109/l) | 52.7 (2.6–117) | 56.7 (23.3–129) | 50.3 (2.1–182) | 0.78 |
| Platelets (×109/l) | 28 (3–251) | 46 (9–108) | 96 (9–1194) | 0.03 |
| Risk stratification | ||||
| IPSS-R (median) | 5 (3–8) | 3 (2–5) | 2.75 (2–7) | 0.03 |
| Marrow blast % (median) | 2 (0–12) | 1 (1–4) | 5 (3–31) | 0.14 |
| Preceding low risk evolution, n (%) | 3 (8) | 0 | 1 (7) | __ |
| WHO diagnosis at time of high-risk evolution, n (%) | ||||
| MDS-SLD | 2 (6) | 0 | 0 | __ |
| MDS-SLD-RS | 1 (3) | 0 | 0 | __ |
| MDS-MLD | 11 (30) | 1 (20) | 1 (7) | __ |
| MDS-EB1 | 5 (14) | 0 | 3 (20) | __ |
| MDS-EB2 | 1 (3%) | 0 | 1 (7) | __ |
| AML | 0 | 0 | 6 (40) | __ |
| MPN/MDS | 0 | 0 | 3 (20) | __ |
| MDS-U | 14 (39) | 1 (20) | 1 (7) | __ |
| hMDS | 2 (6) | 0 | 0 | __ |
| Does not meet WHO criteria # | 0 | 3 (60) | 0 | __ |
| Outcomes, n (%) | ||||
| MDS-EB or AML | 19 (49) | 0 | 10 (67) | __ |
| HSCT | 15 (38) | 4 (80) | 7 (47) | __ |
| Death | 28 (72) | 1 (20) | 7 (47) | __ |
*
Three patients in the monosomy 7 group had unknown marrow morphology
#
WHO criteria defined as dysplasia >10% in at least 1 lineage, or if absent the presence of an MDS defining cytogenetic abnormality with at least 1 cytopenia
Kruskal-Wallis p-value is used
__
p-value not calculated due to small sample size