REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse anti-centrin	Merck Millipore	Cat.#04-1624, RRID:AB_10563501
Rabbit anti-pericentrin	Abcam	Cat.#ab4448, RRID:AB_304461
Rabbit anti-ARL13B	Proteintech	Cat.#17711-1-AP, RRID:AB_2060867
Mouse anti-polyglutamylated Tubulin	AdipoGen	Cat.#AG-20B-0020B, RRID:AB_2490211
Rabbit anti-MUM-1 (MRQ-43)	Cellmarque	Cat.#358R-74
Mouse anti-Ki67 (MIB-1)	Agilent Dako	Cat.#GA626, RRID:AB_2687921
Alexa Fluor 488 goat anti-mouse IgG	Molecular Probes Invitrogen	Cat.#A11017, RRID:AB_143160
Alexa Fluor 488 goat anti-mouse IgG	Molecular Probes Invitrogen	Cat.#A11029, RRID:AB_2534088
Alexa Fluor 568 goat anti-rabbit IgG	Molecular Probes Invitrogen	Cat.#A11036, RRID:AB_10563566
Alexa Fluor 568 goat anti-rabbit IgG	Molecular Probes Invitrogen	Cat.#A11011, RRID:AB_143157
Biological samples
Human bone marrow	This paper	N/A
Human peripheral blood	This paper	N/A
Chemicals, peptides, and recombinant proteins
Vectashield mounting medium	Vector Laboratories	Cat.#H-1000
Vectashield mounting medium with DAPI	Vector Laboratories	Cat.#H-1200
Puromycin	Life Technologies	Cat.#2600023
Hygromycin	Life Technologies	Cat.#10687010
Tetracyclin	SigmaAldrich	Cat.#T7660-5G
FicoLite-H separation medium	Linaris	Cat.#GTF1511KYA
Triton-X-100	ThermoFisher Scientific	Cat.#HFH10
Hoechst 33342 nucleic acid stain	Invitrogen	Cat.#H3570
TRIzol RNA extraction reagent	Invitrogen	Cat.#15596026
Critical commercial assays
RNeasy Mini Kit	Qiagen	Cat.#74104
SV Total RNA Isolation System	Promega	Cat.#Z3101
Small Sample Labeling Protocol	Affymetrix	N/A
GeneChip™ Human Genome U133 Plus 2.0 Array	Applied Biosystems	Cat.#900466
Deposited data
Raw and analyzed data	This paper	EMPIAR DOI: 10.6019/EMPIAR-11243
Code and exported workflows	This paper	Mendeley https://doi.org/10.17632/kf7fnbbbxp.1; Github: https://github.com/mobie/centriole-tomo-examples
Additional supplemental data	This paper	Mendeley, https://doi.org/10.17632/kf7fnbbbxp.1
Gene expression profiling data	This paper; Weinhold et al. (2021); Seckinger et al. (2012)	ArrayExpress: E-MTAB-81/E-GEOD-2658
Experimental models: Cell lines
U-2 OS	ATCC	Cat.#HTB-96, RRID:CVCL_0042
U2OS-PLK4	Konotop et al. (2016)	N/A
BJ	ATCC	Cat.#CRL-2522, RRID:CVCL_3653
Software and algorithms
Konstanz Information Miner (KNIME)	Berthold et al. (2007)	https://www.knime.com/
R 3.5.3	R Core Team (2016)	https://cran.r-project.org/
R ‘Survival‘ Package – 3.1-12	Therneau and Grambsch (2000)	https://CRAN.R-project.org/package=survival
SerialEM	Mastronarde (2005); Schorb et al. (2019)	https://bio3d.colorado.edu/SerialEM/
pyEM	Schorb et al. (2019)	https://git.embl.de/schorb/pyem
IMOD – 4.10.42	Kremer et al. (1996); Mastronarde and Held (2017)	https://bio3d.colorado.edu/imod/
AMIRA 2020.1	ThermoFisher Scientific	https://thermofisher.com/amira-avizo
ImageJ (Fiji) – 1.53	Schneider et al. (2012)	https://imagej.net/software/fiji/
ZEN blue – 2.6	Carl Zeiss Microscopy	https://www.zeiss.com/microscopy/int/products/microscope-software/zen.html
NDP.view2	Hamamatsu	https://www.hamamatsu.com/eu/en/product/life-science-and-medical-systems/digital-slide-scanner/U12388-01.html
MoBIE	Vergara et al. (2021)	https://github.com/mobie/mobie-viewer-fiji