Table 2.
Differential DNA methylation in Braf and Kras mutated intestine as detected by MMB and RRBS
| Mutation | Direction | 8 months |
14 months |
||
|---|---|---|---|---|---|
| RRBS | MMB | RRBS | MMB | ||
| Braf | hypermethylated | 11,253 (0.76%) | 4,423 (1.7%) | 46,757 (3.14%) | 6,276 (2.41%) |
| hypomethylated | 13,908 (0.93%) | 9,423 (3.61%) | 16,399 (1.1%) | 7,808 (2.99%) | |
| Kras | hypermethylated | 5,288 (0.36%) | 1,962 (0.75%) | 30,625 (2.06%) | 3,729 (1.43%) |
| hypomethylated | 2,127 (0.14%) | 2,263 (0.87%) | 5,597 (0.38%) | 3,312 (1.27%) | |
The entire probe set was included in the analysis of MMB and all CpGs with more than 10× coverage for RRBS. Data represent the number of differentially methylated CpGs and the proportion of differentially methylated CpGs compared with all CpGs covered.