Table 1.

Mean relative abundance of microbiota in feces and intestinal contents of offspring from PND 0-49 at phylum and genus level (%).

Stage	Phylum/Genus	Control	TMC3115
PND0	Proteobacteria	13.44	89.74***
	Firmicutes	66.65	9.43**
	Bacteroidota	0.46	0.04*
	Actinobacteriota	19.14	0.55 (P = 0.071)
PND0	Lactobacillus	18.11	2.46*
	Staphylococcus	5.43	0.49*
	Corynebacterium	18.96	0.38 (P = 0.072)
	Streptococcus	25.22	5.38 (P = 0.072)
PND21	Patescibacteria	0.33	0.10*
	Firmicutes	54.93	72.95 (P = 0.054)
	Bacteroidota	42.87	24.84 (P = 0.056)
	Desulfobacterota	0.23	0.53 (P = 0.078)
PND21	Prevotellaceae.UCG.001	1.16	0.15*
	Lactobacillus	38.34	51.80 (P = 0.071)
	Alistipes	1.77	1.07 (P = 0.084)
	Enterorhabdus	0.23	0.48 (P = 0.092)
	Muribaculaceae	30.17	19.60 (P = 0.093)
PND49	Actinobacteriota	0.43	0.84**
	Bacteroidota	45.10	62.65*
	Desulfobacterota	3.25	0.70*
	Firmicutes	49.02	34.99*
PND49	Undefined.Lachnospiraceae	3.06	1.07**
	Lachnospiraceae.NK4A136.group	20.42	4.72**
	Rikenellaceae.RC9.gut.group	0.28	1.28**
	Eubacterium.siraeum.group	1.30	0.34**
	Clostridia.UCG.014	1.07	2.66*
	Muribaculaceae	27.20	42.77*
	Colidextribacter	1.65	0.94*

PND, postnatal day; *: compared with Control, P < 0.05; **: compared with Control, P < 0.01. ***: compared with Control, P < 0.001. Welch’s T test was used for pairwise comparison. PND0, Control group, n = 4, TMC3115 group, n = 2; PND21, n = 7/group; PND49, n = 6/group.