Figure 2.

CSTRG shows anti-viral activity and alleviates lung injury caused by IAV infection in mice. (A) Female BALB/c mice were infected with 6 MLD₅₀ of A/PR/8/34 (H1N1) virus and then were orally administered with CSTRG (4,200 mg/kg/d), Oseltamivir (20 mg/kg/d) for 7 successive days. Samples were collected on the 4th and 7th days post-infection (three mice/group/day). The clinical signs and weight change of infected mice were recorded for 14 successive days (six mice/group/day). (B) The body weight changes. (C) The influenza virus titers in mice lung tissues at the 4th and 7th days post-infection. (D) Lung index was recorded. (E) Sections of the lung tissues were visualized using hematoxylin and eosin (H&E) staining (Magnification: 200×). (F) Pathological score of lung tissue in mice. The data are presented as the means ± SD of 3 or 6 mice per group; compared with blank group, ^#p < 0.05; ^##p < 0.01; compared with model group, *p < 0.05; **p < 0.01.