TABLE 3.
GRADE evidence profile.
| Quality assessment | No of patients | RR/MD (95% CI) | Quality | Importance | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. Of studies | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | SBP combined with CWM | CWM | |||
| MACE | ||||||||||
| 6 | serious a | no serious | no serious | no serious | none | 53/1,643 (3.23%) | 102/1,629 (6.26%) | RR = 0.50 (0.37, 0.68) | ⊕⊕⊕O moderate | CRITICAL |
| Angina Symptom Improvement | ||||||||||
| 27 | serious a | no serious | no serious | no serious | Presenceb | 1,237/1,359 (91.02%) | 991/1,343 (73.79%) | RR = 1.23 (1.19, 1.28) | ⊕⊕OO low | CRITICAL |
| ECG Improvement | ||||||||||
| 16 | serious a | no serious | no serious | no serious | none | 628/747 (84.07%) | 462/736 (62.77%) | RR = 1.34 (1.26, 1.43) | ⊕⊕⊕O moderate | CRITICAL |
| Adverse Events | ||||||||||
| 18 | serious a | serious c | no serious | no serious | none | 287/2,222 (12.92%) | 302/2,200 (13.73%) | RR = 0.75 (0.44, 1.25) | ⊕⊕OO low | CRITICAL |
| Angina Pectoris Frequency | ||||||||||
| 13 | serious a | serious c | no serious | no serious | none | 659 | 645 | MD = −2.83 (−3.62, −2.05) | ⊕⊕OO low | CRITICAL |
| Angina Pectoris Duration | ||||||||||
| 8 | serious a | serious c | no serious | no serious | none | 365 | 363 | MD = −1.32 (−2.04, −0.61) | ⊕⊕OO low | IMPORTANT |
| LVEF | ||||||||||
| 8 | serious a | serious c | no serious | no serious | none | 351 | 348 | MD = 4.88 (3.19, 6.57) | ⊕⊕OO low | IMPORTANT |
| TC | ||||||||||
| 7 | serious a | serious c | no serious | no serious | none | 370 | 364 | MD = −0.59 (−0.78, −0.40) | ⊕⊕OO low | IMPORTANT |
| TG | ||||||||||
| 8 | serious a | serious c | no serious | no serious | none | 402 | 396 | MD = −0.36 (−0.53, −0.19) | ⊕⊕OO low | IMPORTANT |
| LDL-C | ||||||||||
| 8 | serious a | serious c | no serious | no serious | none | 402 | 396 | MD = −0.35 (−0.44, −0.25) | ⊕⊕OO low | IMPORTANT |
| HDL-C | ||||||||||
| 4 | serious a | serious c | no serious | no serious | none | 225 | 221 | MD = 0.31 (0.08, 0.54) | ⊕⊕OO low | IMPORTANT |
SBP, shexiang baoxin pill; CWM, the conventional western medicine; CI, confidence interval; MD, mean difference; RR, risk ratio;
a
Random protocol, blinding, and allocation concealment of some studies were not clear;
b
Quantitative evaluation of the included data indicated publication bias;
c
Heterogeneity (I 2 > 50%, p < 0.05) was found.