Table 1.

Analysis of cytotoxicity and trypanocidal effect of FEX.

IC50 (µM) T. cruzi Epimastigote			IC50 (µM) T. cruzi Amastigote	SI	LD50 (µM) T. cruzi Trypomastigote	SI	CC50 (µM) LLC-MK2
24 h	48 h	72 h	72 h		24 h		96 h
40 ± 10 µM	30 ± 10 µM	23 ± 3 µM	1 ± 0.5 µM	80	50 ± 2 µM	1.6	80 ± 10 µM

IC₅₀: concentration that inhibits 50% of the proliferation of the replicative form.

LD₅₀: concentration that causes lysis in 50% of the trypomastigotes.

CC₅₀: concentration that inhibits the proliferation of host cells by 50%.

SI: selectivity index.