Table 1.
MALAT1 promotes osteogenic differentiation by activating transcriptional factors (TFs) through interacting with miRNAs.
| Cell types | miRNAs | TFs | Osteogenic effects | Ref. |
|---|---|---|---|---|
| hMSCs | has-miR-214-3p | BMP2 | Runx2↑, ALP↑, Alizarin Red S↑ | (43) |
| hBMSCs | miR-143 | Osx | ALP↑, OCN↑, OPN↑, Alizarin Red S↑ | (39) |
| ADSCs | miR-30 | Runx2 | ALP↑, OCN↑, OPN↑, Osx↑ | (40) |
| hBMSCs | miR-96 | Osx | ALP↑, Alizarin Red S↑ | (41) |
| hAVICs | miR-204 | Smad4 | ALP↑, OCN↑, Alizarin Red S↑ | (44) |
| hPLSCs | miR-155-5p | ETS1 | Runx2↑, ALP↑, OCN↑, Alizarin Red S↑, collagen-1↑ | (45) |
| hBMSCs | miR-34c | SATB2 | ALP↑, Alizarin Red S↑, Runx2↑, ATF4↑, Hoxa2↓ | (42) |
| BMSCs | miR-124-3p | IGF2BP1 | ALP↑, Alizarin Red S↑, Wnt/β-catenin↑ | (10) |
| MC3T3-E1 cells | miR-217 | AKT3 | ALP↑, BMP4↑, Col1a1↑, Spp1↑ | (38) |
↑ means up regulation, and ↓ is down regulation.