Table 5.
Comparison of pulmonary and small airway parameters of 14 SSc-ILD patients between baseline and follow-up visit.
|
Baseline visit (n = 14) |
Follow-up visit (n = 14) | B-H adjusted p-value | |
|---|---|---|---|
| Dyspnea# | 10 (71) | 10 (71) | 0.096 |
| Cough# | 4 (29) | 3 (21) | 0.092 |
| FVC (% pred)* | 86.1 ± 25.5 | 85.1 ± 23.8 | 0.086 |
| FEV1/FVC (%)* | 81.5 ± 7.5 | 80.0 ± 5.5 | 0.052 |
| FEF25−75 (% pred)* | 71.1 ± 19.3 | 63.5 ± 13.4 | 0.019 |
| PEF (% pred)* | 97.6 ± 17.0 | 93.1 ± 17.1 | 0.045 |
| sRaw (cmH2O*s)** | 5.59 (3.4–9.96) | 6.08 (3.38–18.08) | 0.075 |
| Raw (cmH2O*s/L)* | 3.05 ± 0.98 | 2.69 ±1.42 | 0.044 |
| sGaw (1/cmH2O/s)** | 0.18 (0.1–0.31) | 0.17 (0.06–0.49) | 0.089 |
| Gaw (L/cmH2O/s)** | 0.37 (0.2–0.6) | 0.4 (0.17–1.88) | 0.043 |
| Rint (% pred)* | 110.1 ± 27.7 | 112.7 ± 26.7 | 0.077 |
| CV/VC (% pred)** | 42.5 (20–193) | 77 (20–170) | 0.021 |
| CV/VC (% pred) >120%# | 1 (10) | 2 (17) | 0.097 |
| phase III slopeN2SBW (% pred)* | 290 ± 176 | 177 ± 142 | 0.012 |
| phase III slopeN2SBW (% pred) >120%# | 7 (78) | 6 (50) | 0.034 |
| DLCO corr (% pred)* | 48.5 ± 19.6 | 54.9 ± 19.5 | 0.042 |
| R4 (kPa/L/s)* | 0.531 ± 0.138 | 0.439 ± 0.143 | 0.014 |
| R5 (kPa/L/s)* | 0.436 ± 0.089 | 0.351 ± 0.078 | 0.003 |
| R20 (kPa/L/s)** | 0.326 (0.217–0.616) | 0.304 (0.195–0.43) | 0.036 |
| R5–R20 (kPa/L/s)* | 0.053 ± 0.083 | 0.040 ± 0.071 | 0.068 |
| R5–R20 ≥0.07 (kPa/L/s)# | 4 (57) | 4 (33) | 0.035 |
| Fres (Hz)* | 18.50 ± 6.88 | 17.89 ± 5.89 | 0.082 |
| X6 (kPa/L/s)** | −0.118 (−0.305 to −0.098) | −0.155 (−0.394 to −0.104) | 0.051 |
*
Data are expressed as mean ± standard deviation.
**
Data are expressed as median (range).
#
Data are expressed as n (%). B-H, Benjamini-Hochberg.
Bold p-values are p-values ≤ 0.05.