Table 4.

Univariate and multivariate analyses of overall survival.

	Univariate			Multivariate
	HR	95% CI	p-value	HR	95% CI	p-value
Age (years)
<60 (n = 336)	Ref			Ref
≥60 (n = 338)	1.25	0.94–1.68	0.123	1.39	1.03–1.87	0.030
Sex
Female (n = 330)	Ref			Ref
Male (n = 344)	1.09	0.81–1.45	0.576	1.18	0.88–1.58	0.274
TMB
Low (n = 555)	Ref			Ref
High (n = 119)	0.57	0.40–0.82	0.012	0.60	0.38–0.94	0.026
Primary tumor location
Left (n = 388)	Ref			Ref
Right (n = 286)	1.13	0.84–1.51	0.417	1.17	0.87–1.57	0.294
Stage at diagnosis
I (n = 48)	Ref			Ref
II (n = 124)	1.11	0.34–3.65	0.867	0.97	0.28–3.34	0.959
III (n = 172)	1.84	0.74–4.58	0.299	2.00	0.62–6.49	0.245
IV (n = 330)	2.29	1.05–5.00	0.142	2.46	0.78–7.77	0.125

TMB, tumor mutation burden; HR, hazard ratio; CI, confidence interval.