TABLE 2.
Comparison of immune responses to ETEC induced by natural disease and vaccination of adult Bangladeshi subjects
| Immune parameter | Mediana
(25th–75th percentile) (n) for:
|
Fold
increaseb
|
Statistical
significancec
|
||||
|---|---|---|---|---|---|---|---|
| Patients
|
Vacinees, day 21 | Day 3 | Day 9 | Day 3 | Day 9 | ||
| Day 3 | Day 9 | ||||||
| CFA-specific | |||||||
| Gut ASCd | 3,300 (400–11,000) (n = 8) | 2,500 (600–4,000)e (n = 4) | 1,200 (400–1,600) (n = 13) | 2.8 | 2.1 | NS | NS |
| Blood ASCd | 1,800 (230–4,800) (n = 10) | 380 (320–430) (n = 6) | 38 (16–99) (n = 27) | 48 | 10 | P = 0.0006 | P = 0.028 |
| Fecal Abf | 0.92 (0.28–2.5) (n = 6) | 18 (8–160) (n = 5) | 3.4 (1.0–6.6) (n = 18) | (3.4) | 5.2 | NS | P = 0.005 |
| CTB-specific | |||||||
| Gut ASC | 5,400 (750–24,000) (n = 12) | 5,100 (3,300–9,200) (n = 9) | 1,400 (0–7,000) (n = 13) | 3.7 | 3.5 | NS | NS |
| Blood ASC | 110 (50–180) (n = 13) | 150 (80–280) (n = 10) | 420 (190–660) (n = 27) | (3.7) | (2.8) | P = 0.028 | NS |
| Fecal Ab | 7.2 (2.5–20) (n = 8) | 33 (9–600) (n = 8) | 35 (11–66) (n = 18) | (5) | 1 | NS | NS |
a
Values are numbers of ASC or titers of antibody (Ab).
b
How many times higher the immune response was in patients than in vaccinees. Parentheses indicate that the immune response was higher in vaccinees.
c
Calculated by the Mann-Whitney test. A P value of <0.05 was considered significant. NS, not significant.
d
CFA/I.
e
The 25th to 75th percentile could not be calculated due to the paucity of patients; instead, the lowest and highest values are given.
f
CS5.