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. 2022 Nov 25;28(1):191–201. doi: 10.1038/s41380-022-01835-w

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Fig. 1 — A As of the end of July 2022, the number of publications on social isolation has increased substantially in the last few years based on a PubMed search using the keywords social isolation, social deprivation, and maternal separation. B Landmarks in SI studies in human and animal models. CREB cAMP response element–binding protein, FSPV fast-spiking parvalbumin-expressing, IL infralimbic, PH prominent h-current, pPVT posterior paraventricular thalamus, mPFC medial prefrontal cortex, MRI magnetic resonance imaging, NAcSh nucleus accumbens shell, NRG-1–ErbB neuregulin-1–Erb-b2 receptor tyrosine kinase 2, Tac2/NkB tachykinin 2/neurokinin B.