Table 3.

Hazard ratios for the association between CI with all-cause and cause-specific mortality by DM or not.

	Non-DM		DM		Interaction†
	Normal cognition	Cognitive impairment	Normal cognition	Cognitive impairment
Participants, no.	2,836	587	900	176
All-cause mortality
Death, no.	346	108	156	57
Model 1 a	1(ref)	1.64(1.31,2.06)*	1(ref)	2.70(1.99,3.67)*	2.77(2.12,3.61)*
Model 2 b	1(ref)	1.64(1.31,2.06)*	1(ref)	2.31(1.69,3.14)*	2.55(1.95,3.32)*
Model 3 c	1(ref)	1.42(1.12,1.81)**	1(ref)	2.10(1.52,2.90)*	2.52(1.93,3.30)*
Model 4 d	1(ref)	1.44(1.13,1.82)**	1(ref)	2.09(1.51,2.89)*	2.46(1.87,3.22)*
CVD mortality
Death, no.	144	52	63	33
Model 1 a	1(ref)	2.52(1.82,3.48)*	1(ref)	3.93(2.57,6.03)*	3.87(2.72,5.52)*
Model 2 b	1(ref)	1.79(1.28,2.49)**	1(ref)	3.29(2.14,5.06)*	3.48(2.44,4.97)*
Model 3 c	1(ref)	1.45(1.02,2.06)***	1(ref)	3.08(1.97,4.85)*	3.32(2.31,4.77)*
Model 4 d	1(ref)	1.48(1.04,2.11)***	1(ref)	3.16(2.02,5.05)*	3.15(2.19,4.55)*
Cancer mortality
Death, no.	118	35	53	9
Model 1 a	1(ref)	1.83(1.25,2.68)**	1(ref)	1.25(0.62,2.55)	1.19(0.61,2.32)
Model 2 b	1(ref)	1.67(1.13,2.47)**	1(ref)	1.17(0.57,2.40)	1.16(0.59,2.26)
Model 3 c	1(ref)	1.50(1.00,2.26)***	1(ref)	1.03(0.50,2.16)	1.14(0.58,2.24)
Model 4 d	1(ref)	1.51(1.01,2.28)***	1(ref)	1.04(0.50,2.16)	1.15(0.59,2.26)

CI, cognitive impairment; DM, diabetes mellitus; CVD, cardiovascular disease; HRs, hazard ratios.

^aAn unadjusted model.

^bAdjusted for age and gender.

^cFurther adjusted for residence, education, marriage, smoking status, alcohol drinking, exercise, BMI.

^dFurther adjusted for WC, chronic diseases (hypertension, dyslipidemia, coronary disease, COPD, and tumor), TC, TG, uric acid.

*p<0.001; **p<0.01; ***p ≤ 0.05. ^†Cognitive function status ∗Diabetes category.