. 2022 Nov 14;13:1003626. doi: 10.3389/fimmu.2022.1003626

Table 3.

Potential biomarkers for the identification of tumor specific T cell in human cancers.

Tumor types	Biomarkers	Tissue of origin	Stage of disease	Reference
Melanoma	PD-1⁺	Tumor and Peripheral blood	Stage IV;	(16, 21, 22, 26, 27)
	CD39⁺	Tumor and Peripheral blood	Stage IIIC-IVB;	(42, 80, 88, 93)
	CD39⁺	Tumor and Peripheral blood	Stage IIIC-IVB;
	CD103⁺	Tumor	Stage I-IV;	(61)
	CD137⁺	Tumor	Stage IV;	(17, 75)
	CD39⁺PD-1⁺	Tumor	Stage IV;	(83)
	CD39⁺CD103⁺	Tumor	N/A	(19)
	CD137⁺TNF⁺IFN-γ⁺	Tumor	Stage IV;	(79)
	Tcf1⁺PD-1⁺	Tumor	N/A	(100, 101)
Ovarian Cancer	CD137⁺	Tumor	N/A	(77)
	CD39⁺PD-1⁺	Tumor	Stage I-IV;	(82)
	CD39⁺CD103⁺	Tumor	N/A	(19)
	CD39⁺CD103⁺PD-1⁺	Tumor	Stage I-IV;	(89)
	PD-1⁺CD137⁺	Tumor	Stage IA-IIIC;	(74, 90)
Non-Small Cell Lung Cancer	CD39⁺	Tumor	Stage I-IV;	(7, 40)
	CD103⁺	Tumor	Stage I-IVB;	(50, 51, 56, 60, 62–64)
	CD39⁺CD103⁺	Tumor	N/A	(19)
	Tcf1⁺PD-1⁺	Tumor	Stage I-II;	(96)
Colorectal Cancer	PD-1⁺	Tumor	Stage IIA-IVA;	(23)
	CD39⁺	Tumor	Stage I-IV;	(7)
	CD103⁺	Tumor	N/A	(19)
	CD39⁺CD103⁺	Tumor	Stage I-IV;	(85, 87)
	PD-1⁺ICOS⁺	Tumor	N/A	(93)
Hepatocellular Carcinoma	CD39⁺	Tumor	BCLC stage A-C;	(35, 36)
	CD103⁺	Tumor	Stage I-IV;	(55, 78)
	PD-1⁺CD137⁺	Tumor	N/A	(91)
	Tcf1⁺PD-1⁺	Tumor	Stage II-III;	(98)
Breast Cancer	PD-1⁺	Tumor	Stage 0-IIB;	(23)
	CD39⁺	Tumor	Stage 0-IV;	(41)
	CD103⁺	Tumor	Stage I-IV;	(52, 54)
Gastrointestinal Cancers*	PD-1⁺	Peripheral blood	N/A	(28)
Gastric Cancer	Tcf1⁺PD-1⁺	Tumor	Stage II-III;	(95)
Renal Cell Carcinoma	PD-1⁺	Tumor and Peripheral blood	Stage IV;	(27)
	CD137⁺	Tumor	Fuhrman grade I-IV;	(80)
	Tcf1⁺PD-1⁺	Tumor	Stage I-IV;	(97)
Cervical Cancer	CD39⁺	Tumor	N/A	(38)
	CD103⁺	Tumor	Stage IA2-IVA;	(49)
	CD39⁺PD-1⁺	Tumor	N/A	(84)
Vulvar Squamous Cell Carcinoma	CD39⁺	Tumor	N/A	(38)
Oropharyngeal Squamous Cell Carcinoma	CD39⁺	Tumor	N/A	(38)
Oropharyngeal Squamous Cell Carcinoma	CD103⁺	Tumor	Stage I-III;	(57)
Endometrial Adenocarcinoma	CD103⁺	Tumor	FIGO stage I-IV;	(53)
	CD39⁺PD-1⁺	Tumor	FIGO stage I-IV;	(82)
	CD39⁺CD103⁺	Tumor	FIGO stage IA-IIIC;	(86)
Esophageal Squamous Cell Carcinoma	CD103⁺	Tumor	Stage I-III;	(18)
Head and Neck Squamous Cell Carcinoma	CD39⁺PD-1⁺	Tumor	N/A	(84)
	CD39⁺CD103⁺	Tumor	Stage II-IVA;	(19, 88)
	PD-1⁺ICOS⁺	Tumor	N/A	(93)
Urothelial Carcinoma	CD103⁺	Tumor	Stage I;	(62)
Bladder Cancer	CD39⁺	Tumor	Stage I-IV;	(37)
Bladder Cancer	CD103⁺	Tumor	Stage I-IV;	(47)

*Gastrointestinal Cancers including pancreatic、gastroesophageal、colon and bile duct cancer. N/A, Not Applicable.