Table 2.
Characteristics of each study included in our review.
| Study, year | No. of patients | Age (mean years), sex (% F) | Design | No. of aneurysms, status | Aneurysm sizes | Neck width | Fusiform, dissecting, pseudoaneur-ysm or blister (%) | Circulation (%) | Locations (%) | No. of the usage of the pipline shield device |
Adjunctive devices (%) |
Mortality rate (%) |
Morbidity rate*(%) |
Adequate occlusion rate (%) |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| One device | Multiple devices | Unsuccessful | Devices per aneurysm | Coiling | Balloon | |||||||||||||
| Atasoy et al. (10) | 41 | 56, 68.3% | Retrospective study | 52 unruptured | 60.8% <10 mm 34.6% 10–25 mm 3.8% ≥ 25 mm | 5.0, 1.0–21.0 mm (Mean, Range) |
5.80% | Anterior circulation:88.5% Posterior circulation:11.5% |
3.8% ICA C4 55.7% ICA paraophthalmic segment 23.1% ICA C7 3.8% ICA terminal segment 1.9% MCA M1 5.8% BA 3.8% VA 1.9% PCA |
1 device per aneurysm: 41 | 2 devices per aneurysm;2 | One device | 0.86 | 28.8%(15/52) | - | 2.4% (1/41) |
7.3% (3/41) |
69.2% (36/52) at 6 months; 82.7% (43/52) at 18 months. |
| Manning et al. (11) | 14 | 63, 85.7% | Retrospective study | 14 ruptured | 35.7%>10 mm 64.3% ≤ 10 mm | Unknown | 50% | Anterior circulation:57.1% Posterior circulation:42.9% |
21.4% MCA M1 14.3% ACA A1/A2 7.1% AChA 7.1% AcommA 7.1% ACA A2 21.4% VA 14.3% PICA 7.1% PcommA |
Unknown | Unknown | - | 1.2 | 85.7% (12/14) |
- | 7.1% (1/14) |
35.7% (5/14) |
50.0% (7/14) patients with immediate aneurysm occlusion |
| Martinez-Galdamez et al. (12) | 50 | 53, 82% | Prospective study | 50 unruptured | 76% < 10 mm 22% 10–25 mm 2% ≥ 25 mm | Unknown | 2.00% | Anterior circulation:94% Posterior circulation:6% |
94% ICA 6% VA | Unknown | Unknown | Three devices | 1.12 | - | - | 0 | 14% (7/50) |
76.3%(29/38) at 6 months; 81.8%(27/33) at 12 months. |
| Pikis et al. (13) | 33 | 54.4, 81.8% | Prospective study | 31 unruptured 7 ruptured |
68.4% < 10 mm 21.1% 10–25 mm 3% ≥ 25 mm | Unknown | 7.90% | Anterior circulation:92.1% Posterior circulation:7.9% |
92.1% ICA 7.9% BA | 1 device per aneurysm: 35; 1 device for three aneurysms: 1 |
2 devices per aneurysm: 1 | - | 0.97 | 100%(38/38) | - | 0 | 18.18% (6/33) |
Not pursued. |
| Rice et al. (14) | 204 | 54.8, 81.4% | Prospective study | 166 unruptured 38 ruptured |
50% < 7 mm 33.8% 7–13 mm 13.7% 13–25 mm 2.5% ≥ 25 mm | 4.6 ± 2.39 mm(mean ± SD) | 4.90% | Anterior circulation:93.6% Posterior circulation:6.4% |
1.5% ACA A1 2.5% ACA A2 5.9% AcommA 1.0% MCA M1 0.5% MCA M2 6.4% MCA bifurcation 1.0% ICA C1 0.5% ICA C2 1.5% ICA C3 3.9% ICA C4 8.8% ICA C5 41.2% ICA C6 19.1% ICA C7 6.4% VA V4 |
1 device per aneurysm: 177 | 2 devices per aneurysm;23 | Four devices | 1.1 | 18.6% (38/204) |
10.8% (22/204) |
1.0% (2/204) |
6.4% (13/204) |
70.8% (92/130) at 6 months; 77.2% (61/79) at 12 months. |
| Trivelato et al. (15) | 151 | 52.7, 79.5% | Prospective study | 175 unruptured 7 ruptured |
The mean aneurysm size was 7.0 mm; 27 (14.8%) aneurysms were large, and 7 (3.8%) were giant. |
4.1 ± 2.1 mm(mean ± SD) | 7.10% | Anterior circulation:93.4% Posterior circulation:6.6% |
6.5% ACA 11.0% Cavernous 8.2% Communicating 10.4% MCA 53.8% Paraophthalmic 11.1% Other | 1 device per aneurysm: 177 | 2 devices per aneurysm: 4; 3 devices per aneurysm: 1 |
- | 1.03 | 17%(31/182) | 11.5% (18/182) |
0.66% (1/151) |
6.0% (9/151) |
79.7% (55/69) at 6 months; 85.3% (29/34) at 12 months. |
| Yeomans et al. (16) | 31 | 58.8, 84.1% | Prospective study | 32 unruptured | 50% < 10 mm 41% 10–25 mm 9% ≥ 25 mm | 5.9 ± 3.0 mm(mean ± SD) | 100% | Anterior circulation:94% Posterior circulation:6% |
3.1% ACA 15.6% ICA C4 6.3% HA 3.1% MCA bifurcation 18.8% ICA paraophthalmic 46.9% PcommA 3.1% Distal BA 3.1% Proximal BA |
1 device per aneurysm: 29 | 2 devices per aneurysm: 3 | - | 1.09 | 28.1% (9/32) |
- | 0 | 6.5% (2/31) |
74.2% (23/31) at 6 months. |
ACA, anterior cerebral artery; AcommA, anterior communicating artery; AChA, anterior choroidal artery; A1/A2, first/second segment; BA, basilar artery; C1, cervical segment; C2, petrous segment; C3, lacerum segment; C4, cavernous segment; C5, clinoid segment; C6, ophthalmic segment; C7, communicating segment; F, female; HA, hypophyseal artery; ICA, internal carotid artery; MCA, middle cerebral artery; M1, pre-bifurcation segment; M2, post-bifurcation segment; No, number; PCA, posterior cerebral artery; PcommA, posterior communicating artery; PICA, posterior inferior cerebellar artery; SD, standard deviation; VA, vertebral artery; V4, intradural segment;
*
Perioperative and postoperative 1 year such as ischemic/hemorrhagic stroke and other complications.