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Modelled interactions between SARS-CoV-2 RdRp and ponatinib, capmatinib, lonafarnib, and tedizolid phosphate. Protein–ligand interactions formed between the screen hit compounds (grey) by hydrophobic interaction (grey dotted line), salt bridges (dotted yellow line), and H-bonds (solid yellow line) with numbered residues (cyan) in the binding tunnel of RdRp are shown
