FIG. 2.

Effects of inhibitors of prostaglandin synthesis on MALP-2-mediated bone resorption. Both halves of calvarium pairs were preincubated as described for Fig. 1 and then treated with either MALP-2 or vehicle without MALP-2 (no MALP-2). Indomethacin (open bars), hydrocortisone (hatched bars), and flurbiprofen (solid bars) at a concentration of 10⁻⁶ M were added to one half of the calvarium pairs, and the bones were incubated for 72 h. Values are means ± SEM of 10 pairs (MALP-2) and 5 pairs (no MALP-2). ∗, ∗∗, and ∗∗∗, significantly different from control (no inhibitor of prostaglandin synthesis) value; P < 0.05, P < 0.01, and P < 0.001, respectively.