FIG. 3.

Effect of IFN-γ on NO production and MALP-2-induced bone resorption in murine calvaria. After 24 h of preincubation, the calvarium pairs were cultured for 48 h in the presence of MALP-2. One half was (hatched bars) and the other half was not (open bars) treated with IFN-γ (200 U/ml). NO production (A) and bone resorption (B) are given as means ± SEM of five calvarium halves. SEMs smaller than the symbols are not drawn. ∗ and ∗∗, significantly different from value for untreated half; P < 0.05 and P < 0.001, respectively.