FIG. 5.

Effect of MALP-2 on the bone-resorbing activity of isolated osteoclasts. Rat osteoclasts adhering to dentine slices were incubated for 24 h in the presence of vehicle (0 nM MALP-2) and various concentrations of MALP-2. The number of TRAP-positive multinucleated cells (osteoclasts; open bars) and of pits (hatched bars) (A) and the ratio of pits to TRAP-positive mononuclear cells (B) are given as means ± SEM of n (given in parentheses) slices. ∗, significantly different from value for 0 nM MALP-2; P < 0.05.