Table 3.
Association between clinicopathologic characteristics and mean expression (% positive expression) of GAGs and collagen types (t test and ANOVA, P<0.05).
| Characteristics | HS | CS | Col I | Col III | Col IV | Col V |
|---|---|---|---|---|---|---|
| Age (years) | ||||||
| ≤65 | 1.52 ± 0.16 | 12.21 ± 1.06 | 2.85 ± 0.21 | 23.67 ± 1.00 | 3.64 ± 0.35* | 13.63 ± 0.87 |
| > 65 | 1.58 ± 0.15 | 11.59 ± 1.09 | 2.75 ± 0.28 | 26.60 ± 1.13 | 5.03 ± 0.58 | 15.32 ± 1.02 |
| Gender | ||||||
| Male | 1.59 ± 0.16 | 10.95 ± 0.97 | 3.09 ± 0.23 | 25.52 ± 1.01 | 5.12 ± 0.53 | 13.94 ± 0.93 |
| Female | 1.50 ± 0.16 | 13.10 ± 1.18 | 2.47 ± 0.23 | 24.45 ± 1.16 | 3.29 ± 0.34** | 15.01 ± 0.96 |
| Tobacco History | ||||||
| Smoker/Former-smoker | 1.63 ± 0.16 | 10.71 ± 0.93 | 2.91 ± 0.21 | 26.69 ± 0.99 | 3.82 ± 0.40 | 15.15 ± 0.93 |
| Non-smoker | 1.24 ± 0.22 | 14.52 ± 2.10 | 2.94 ± 0.46 | 25.78 ± 2.15 | 4.20 ± 0.66 | 15.79 ± 1.87 |
| Histotypes | ||||||
| ADC | 1.52 ± 0.15 | 13.31 ± 0.98 | 2.72 ± 0.20 | 25.58 ± 1.03 | 4.41 ± 0.43 | 14.17 ± 0.82 |
| SqCC | 1.55 ± 0.18 | 10.20 ± 1.23 | 3.01 ± 0.30 | 23.80 ± 1.20 | 4.14 ± 0.60 | 14.63 ± 1.26 |
| LCC | 1.86 ± 0.43 | 7.18 ± 2.62 | 2.57 ± 0.82 | 26.50 ± 2.97 | 4.07 ± 1.43 | 15.85 ± 2.86 |
| T stage | ||||||
| T1 | 1.19 ± 0.16 | 13.98 ± 1.67 | 2.46 ± 0.34 | 24.47 ± 1.56 | 3.72 ± 0.52 | 15.50 ± 1.41 |
| T2 | 1.76 ± 0.17 | 11.74 ± 1.07 | 2.99 ± 0.25 | 26.15 ± 1.13 | 4.92 ± 0.54 | 13.00 ± 0.82 |
| T3 | 1.23 ± 0.20 | 9.67 ± 1.46 | 2.50 ± 0.31 | 23.44 ± 1.46 | 3.63 ± 0.68 | 16.61 ± 1.91 |
| T4 | 2.43 ± 0.69 | 12.05 ± 2.55 | 3.91 ± 0.28 | 22.83 ± 2.55 | 3.44 ± 0.74 | 14.98 ± 1.54 |
| N stage | ||||||
| N0 | 1.49 ± 0.13 | 12.31 ± 0.97 | 2.78 ± 0.20 | 25.79 ± 0.93 | 4.41 ± 0.43 | 15.50 ± 0.88 |
| N1 | 1.50 ± 0.28 | 10.69 ± 1.51 | 2.80 ± 0.37 | 23.10 ± 1.52 | 4.41 ± 0.75 | 13.40 ± 1.13 |
| N2 | 1.91 ± 0.35 | 11.84 ± 1.97 | 2.95 ± 0.46 | 24.30 ± 2.33 | 3.59 ± 0.75 | 10.85 ± 1.34*# |
| Pathologic stage | ||||||
| I | 1.35 ± 1.16 | 14.30 ± 1.38 | 2.83 ± 0.34 | 26.90 ± 1.45 | 4.31 ± 0.67 | 14.84 ± 1.27 |
| II | 1.53 ± 0.16 | 10.34 ± 1.08&## | 2.60 ± 0.22 | 24.68 ± 1.12 | 4.63 ± 0.48 | 14.93 ± 0.98 |
| IIIA | 1.95 ± 032 | 11.47 ± 1.57 | 3.38 ± 0.32 | 23.00 ± 1.38 | 3.66 ± 0.59 | 12.65 ± 1.30 |
| Tumor size | ||||||
| ≤3 cm | 1.56 ± 0.19 | 13.72 ± 1.27 | 2.67 ± 0.25 | 25.43 ± 1.17 | 3.84 ± 0.42 | 14.51 ± 0.97 |
| >3 cm | 1.57 ± 0.14 | 10.65 ± 0.92* | 2.90 ± 0.23 | 24.90 ± 1.03 | 4.64 ± 0.50 | 14.48 ± 0.93 |
| Relapse | ||||||
| No | 1.60 ± 0.16 | 11.71 ± 0.95 | 3.02 ± 0.23 | 25.57 ± 1.05 | 4.21 ± 0.47 | 15.10 ± 0.98 |
| Yes | 1.55 ± 0.20 | 13.19 ± 1.75 | 2.50 ± 0.29 | 23.38 ± 1.47 | 4.40 ± 0.59 | 14.24 ± 1.19 |
| Adjuvant treatment | ||||||
| Chemotherapy | ||||||
| No | 1.56 ± 0.15 | 12.56 ± 1.10 | 2.69 ± 0.24 | 25.58 ± 1.06 | 4.75 ± 0.50 | 15.68 ± 0.89 |
| Yes | 1.51 ± 0.17 | 11.03 ± 1.07 | 2.94 ± 0.24 | 24.48 ± 1.16 | 3.57 ± 0.41& | 12.71 ± 1.04* |
| Radiotherapy | ||||||
| No | 1.52 ± 0.14 | 12.00 ± 0.93 | 2.95 ± 0.20 | 24.89 ± 0.93 | 4.40 ± 0.41 | 14.78 ± 0.88 |
| Yes | 1.58 ± 0.19 | 11.70 ± 1.43 | 2.38 ± 0.28 | 25.72 ± 1.47 | 3.86 ± 0.57 | 13.50 ± 0.93 |
*P>0.05; **P>0.01; #N0 vs. N2, P=0.05; &P=0.07; ##Stage I vs. Stage II P=0.06
HS, heparan sulfate; CS, chondroitin sulfate; Col I, collagen type I; Col III, collagen type III, Col IV, collagen type IV; Col V, collagen type V; ADC, lung adenocarcinoma; SqCC: lung squamous cell carcinoma; LCC, large cell carcinoma.
Bolded values refer to a P-value with statistical significance (P<0.05).