Table 1.
Comparison of the Performance of Different Multiple Organ Dysfunction Scoring Tools
| Criteria | SCORES | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PIM-2/3 | PRISM-III | PELOD-2 (dPELOD-2) | qPELOD | SOFA | pSOFA/mSOFA | LODS | MOSF/MODS (count) | PeRF | SICK | PEDIA | BEP | TISS | Arzeno 2015 | Meyer 2005 |
|
| Number of studies | 5 | 4 | 8 | 1 | 4 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Validation | |||||||||||||||
| Reference standard | Death | Death | Death | Death | Death | Death | Death | Death | Death | Death | Death | Death | Death | Death | Death |
| Case-mix applied to | PICU, mening | PICU, sepsis, RRT | PICU | Sepsis | PICU, RRT, GI | CICU, PICU | Hosp fever | PICU, ARDS, Sepsis | ARDS | Hosp fever, PICU | Hosp fever | Mening | PICU | PICU brain | PICU oncology |
| Validity | |||||||||||||||
| Construct (score reflects MODS?) | NO | YES | YES | NO | YES | YES | NO | YES | YES | NO | NO | NO | NO | YES | YES |
| Content (score includes all organs?) | NO | YES | NO | NO | YES | YES | NO | YES | YES | NO | NO | NO | NO | YES | YES |
| Criterion (↑score → ↑ death) | YES | YES | YES | YES | YES | YES | YES | YES | YES | YES | YES | YES | YES | YES | YES |
| Discrimination | |||||||||||||||
| AUROC | Poor-Good | Mod-Good | Good | Good | Mod-Good | Good | Good | Good | Mod-Good | Mod-Good | Good | Mod | Mod | Mod | NR |
| Calibration | Good | Good | Poor to Good | Good | Mod to Good | Good | Good | Good | Poor to Good | Poor to Good | Good | Unknown | Unknown | Good | Unknown |
| Reliability | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown |
| Ease of Use | Mod | Mod | Mod | Good | Good | Good | Good | Good | |||||||
| Ease of interpretation | Mod | Mod | Good | Good | Good | Good | Good | Good | |||||||
| External validity/generalizability | Unknown | Unkown | Unknown | Unknown | Mod | Unkown | Unkown | Good | Unknown | Mod | Unknown | Unknown | Unknown | Unknown | Unknown |
Abbreviations: PIM-2/3, Pediatric Index of Mortality, versions 2 and 3; PRISM III, Pediatric Risk of Mortality, version 3; PELOD-2, Pediatric Logistic Organ Dysfunction, version 2; dPELOD-2, Pediatric Logistic Organ Dysfunction on day 1; SOFA, Sequential Organ Failure Assessment; pSOFA. Sequential Organ Failure Assessment, modified for use in children; mSOFA modified SOFA; LODS, Logistic Organ Dysfunction Score; MOSF/MODS, Multiple Organ Dysfunction Score; PeRF, Pediatric Respiratory Failure score; SICK, Signs of Inflammation in Children that can Kill score; PEDIA, _Pediatric Early Death Index for Africa Score; BEP, base excess and platelet count at presentation score; TISS; Therapeutic Intervention Scoring System; PICU, pediatric intensive care unit; RRT, renal replacement therapy; CICU, cardiac intensive care unit; Hosp fever, hospitalized patients with fever; ARDS, acute respiratory distress syndrome; Mening, meningococcal disease.