Table 2.
Comparison of Characteristics of Main Organ Dysfunction Assessment Tools
| Scores | PIM-3 | PRISM-III and IV | PELOD-2 (dPELOD-2) | qPELOD | pSOFA | 2005 IPSDCC (Goldstein) |
|---|---|---|---|---|---|---|
| Organ systems | Not specific to organs | Not specific to organs | CVS + metabolic (lactate), respiratory, hematological, renal, CNS | CVS, CNS | CVS, respiratory, hematological, hepatic, renal, CNS | CVS, respiratory, hematological, hepatic, renal, CNS |
| Main purpose (at time of design of the score) | Prediction of mortality, ICU benchmarking | Prediction of mortality, ICU benchmarking | Description of severity | Prediction of mortality in sepsis | Description of severity | Diagnosis of organ dysfunction |
| Number of items | 11 | 17 | 10 | 3 | 8 (12 if counting SpO2 and individual inotropes) | 18 |
| Number of laboratory items (N of laboratory items available as POC, i.e. blood gas components, glucose and lactate) | 2 (2) | 12 (5) | 6 (3) | 0 | 3 (1) | 9 (3) |
| Development methods | Derivation cohort Australia, New Zealand, Ireland, and the United Kingdom N= 53,112 in 2010–2011 | Derivation cohort U.S. N=10,078 in 2011–2013 | Derivation cohort French/Belgium N=3,671 in 2006–2007 | A priori (aligned with qSOFA and PELOD-2) | A priori (aligned with SOFA and PELOD-2) | A priori (expert statement) |
| Validation/calibration | Multiple validations | Multiple validations | Multiple validations | N/A | Multiple validations | N/A |
| Time frame | Within 60min of admission including first contact outside PICU by PICU team | first 4hrs of PICU admission, minus 2hrs to 4hrs for laboratory variables | Daily every 24hrs of PICU admission | First 24hrs of PICU admission | Daily every 24hrs of PICU admission | Not specified |
| Patient information | Yes | Yes in PRISM-IV | No | No | No | No |
| Treatment information | Yes (ventilation) | No | Yes (ventilation) | No | Yes (ventilation, vasoactives) | Yes (ventilation, vasoactives) |
| Applicability: | ||||||
| outside PICU | Poor | Poor | Moderate | Very good | Moderate | Good |
| resource-limited setting | good | Poor | Poor | Very good | moderate | moderate |
Abbreviations: PIM-3, Pediatric Index of Mortality, version 3; PRISM III, IV, Pediatric Risk of Mortality, versions III, IV; PELOD-2, Pediatric Logistic Organ Dysfunction, version 2; dPELOD-2, Pediatric Logistic Organ Dysfunction on day 1; qPELOD, Quick Pediatric Logistic Organ Dysfunction; pSOFA, Sequential Organ Failure Assessment, modified for use in children; IPSDCC, International Pediatric Sepsis Definition Consensus Conference; CVS, cardiovascular system; CNS, central nervous system