Figure 2.

Comparison of cytokine, chemokine and related molecule levels between autoantibody-associated diseases. (A) Volcano Plot comparing MOGAD with NMOSD of all 65 cytokines, chemokines and related molecules measured by bead-based assay 1. Significant hits are shown above the significant level after correction for multiple comparisons using two-stage step-up (Benjamini, Krieger and Yekutieli) and FDR of 1% correction indicated as a red dotted line. (B) Heatmap showing mean ranks of significantly different cytokines, chemokines comparing MOGAD with NMOSD. APRIL, a proliferation-inducing ligand; BAFF, B cell activation factor; MCP, monocyte chemoattractant protein; MOGAD, myelin oligodendrocyte glycoprotein associated disease; MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder; TNF, tumor necrosis factor; TRAIL, TNF-related apoptosis-inducing ligand.