Figure 4.

Cytokines, chemokines and related molecules significantly associated with MOGAD and/or NMOSD. (A) Venn diagram of significantly altered cytokines/chemokines/related molecules of pairwise Mann-Whitney U test comparison with MS patients. In red are those analytes which specifically differed in MOGAD patients compared to MS. In the green circle are those that were significantly altered in NMOSD patients compared to MS. In the overlapping part labeled as MOGAD+NMOSD are those that significantly differed for both MOGAD and NMOSD compared to MS. The blue circle shows those cytokines/chemokines that significantly differed in the direct comparison of NMOSD with MOGAD. APRIL, a proliferation-inducing ligand; BAFF, B cell activation factor; BLC, B lymphocyte chemoattractant; CD40L, CD40 ligand; ENA-78, epithelial neutrophil-activating peptide-78; FGF, fibroblast growth factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; GRO, growth-regulated oncogene; HGF, hepatocyte growth factor; IFN, interferon; IL, interleukin; IP, interferon-ɣ-induced protein; I-TAC, interferon-inducible T cell α-chemoattractant; LIF, leukemia inhibitory factor; MCP, monocyte chemoattractant protein; M-CSF, macrophage colony-stimulating factor; MDC, macrophage-derived chemokine; MIF, macrophage migration inhibitory factor; MIG, monokine induced by interferon-ɣ; MIP, macrophage inflammatory protein; MMP, matrix metalloproteinase; MOGAD, myelin oligodendrocyte glycoprotein associated disease; MS, multiple sclerosis; NGF, nerve growth factor; NMOSD, neuromyelitis optica spectrum disorder; SCF, stem cell factor; SDF, stromal cell-derived factor; TNF, tumor necrosis factor; TRAIL, TNF-related apoptosis-inducing ligand; TSLP, thymic stromal lymphopoietin; TWEAK, tumor necrosis factor-like weak inducer of apoptosis; VEGF, vascular endothelial growth factor.