Table 2. ΔADC parameters, ΔTV, T-stage, and N-stage of the primary tumor and patient age for prediction of treatment response.
| Variables | All patients (n=19) | Responders (n=15) | Non-responders (n=4) | P value |
|---|---|---|---|---|
| ΔADCmean | 0.09±0.20 | 0.12±0.21 | −0.04±0.09 | 0.271 |
| ΔADCmedian | 0.11±0.19 | 0.15±0.20 | −0.04±0.08 | 0.089 |
| ΔADC25 | 0.13±0.24 | 0.19±0.23 | −0.09±0.15 | 0.035* |
| ΔADC75 | 0.08±0.20 | 0.11±0.21 | 0.00±0.05 | 0.317 |
| ΔADCkurtosis | 0.05±0.48 | 0.07±0.53 | 0.02±0.30 | 0.764 |
| ΔADCskewness | −0.16±1.09 | −0.05±1.16 | −0.55±0.73 | 0.484 |
| ΔADCentropy | 0.01±0.07 | 0.02±0.07 | −0.04±0.05 | 0.089 |
| ΔADCmin | 1.25±2.83 | 1.78±2.98 | −0.73±0.36 | 0.009* |
| ΔADCmax | −0.03±0.24 | −0.08±0.19 | 0.17±0.31 | 0.110 |
| ∆TV | −0.28±0.31 | −0.34±0.23 | −0.04±0.48 | 0.271 |
| T stage (T1–2 vs. T3–4) | 7/12 | 6/9 | 1/3 | 0.591 |
| N stage (N0–1 vs. N2–3) | 9/10 | 7/8 | 2/2 | 0.908 |
| Age (years) | 55.9±6.91 | 56.5±7.74 | 54.0±0.82 | 0.315 |
*, statistically significant after Mann–Whitney U test. ΔADC, interval changes of ADC values were generated by calculating the difference in pretreatment and posttreatment (after one cycle of induction chemotherapy) ADC values divided by the pretreatment ADC value; ∆TV, interval changes of primary tumor volume were generated by calculating the difference in pretreatment and posttreatment (after one cycle of induction chemotherapy) primary tumor volume divided by the pretreatment primary tumor volume; ADC, apparent diffusion coefficient; TV, primary tumor volume.