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. 2022 Aug 28;14(6):1295–1310. doi: 10.1016/j.jcmgh.2022.08.008

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Sampling site of origin and IEO passage number are associated with the main components of DNAm variation. (A) Outline of study design. (B) Scree plot showing DNAm variance accounted for by each PC and association with sample variables. P values were generated with a Spearman correlation for continuous variables or an analysis of variance for categoric variables. (C) PC1 and PC2 of IEO genome-wide DNAm profiles (cohort 1). (D) Heatmap showing DNAm of the top 500 CpGs differentially DNAm between small- and large-bowel IEOs. (E) PC2 and PC3 of IEO DNAm profiles. Samples are colored by passage number. Lines connect samples derived from the same patient profiled at different passages. (F) The association between chronological and epigenetic age is shown, with points colored by the passage of the IEO. As in panel B, variance was accounted for by PCs in validation cohorts. (G) Cohort 2. (H) Cohort 3. SC, sigmoid colon.