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. 2022 Aug 28;14(6):1295–1310. doi: 10.1016/j.jcmgh.2022.08.008

Figure 6.

Figure 6

Passage affects DNAm in specific regions of the genome. (A and B) Enrichment of passage-associated CpGs across genomic regions expressed as fold change relative to the total number of CpGs present on the EPIC array. Standard error bars indicate mean fold change for the error across 1000 random samplings. (C) Distance of passage-associated CpGs from origin replication complex (ORC) sites. (D) Schematic showing location of passage-associated DNAm changes relative to the origins of replication.