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. 2022 Aug 2;14(6):1311–1331. doi: 10.1016/j.jcmgh.2022.07.011

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SC79 could activate AKT pathway in regenerated liver. (A) Western blot analysis of hepatic p-AKT (Ser473), p-AKT (Thr308), AKT, FoxO1, p-FoxO3a (Ser253), p-FoxO3a (Ser318/S321), and FoxO3a expression in control (Ctrl) and R-LKO mice at 36 hours after PH. (B) Western blot analysis of SC79-treated hepatic p-AKT (Ser473), p27, p-FoxO3a (Ser318/S321), and PCNA expression in Ctrl and R-LKO mice at 36 hours after PH. The VersaDoc Imaging System (Bio-Rad) and software were used to visualize proteins.