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. 2022 Aug 2;14(6):1311–1331. doi: 10.1016/j.jcmgh.2022.07.011

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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The PPAR-α pathway was decreased in mTORC2 KO liver during liver regeneration. (A) Relative mRNA expression levels of ketogenesis-associated genes at the indicated time points in Ctrl (green line) or R-LKO liver (red line). The expression of PPAR-α, Cytb, Hmgcs2, and Hmgcl were normalized to the levels of control hepatocytes before PH (0 h). Means ± SD, 4 mice per time point. (D) Fatty acid metabolic model in the normal liver between 0 and 36 hours after PH. The VersaDoc Imaging System (Bio-Rad) and software was used to visualize proteins. ImageJ was used to quantify the band densities. ∗P < .05, ∗∗P < .01 and ∗∗∗P < .001.