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. Author manuscript; available in PMC: 2022 Nov 28.
Published in final edited form as: Nat Chem Biol. 2022 Jun 20;18(8):859–868. doi: 10.1038/s41589-022-01049-9

Extended Data Fig. 1 ∣. Mass spectroscopy characterization of empty and ligand bound hpMR1 states.

Extended Data Fig. 1 ∣

LC–MS analysis of purified a, empty hpMR1, b, DCF/hpMR1, c, 5-OP-RU/hpMR1, and d, Ac-6-FP/hpMR1 complexes. In each panel, the top graph shows the total ion chromatogram (TIC) while the bottom panel shows the deconvoluted m/z data (Da) of the selected TIC region highlighted in dotted boxes. The expected and observed molecular weights of each species are noted.