Table 2.
Comparisons of ovarian stimulation and semen characteristics according to the fertilisation rate
| Total (n=11 598) |
Control (n=10 920) |
LFR (n=318) |
TFF (n=360) |
P value (LFR vs control) | P value (TFF vs control) | |
| Ovarian stimulation | ||||||
| Ovarian stimulation protocol, n (%) | <0.001 | <0.001 | ||||
| GnRH antagonist | 4387 (37.8) | 4229 (38.7) | 103 (32.4) | 55 (15.3) | ||
| Follicular phase GnRH agonist | 3887 (33.5) | 3683 (33.7) | 159 (50.0) | 45 (12.5) | ||
| Luteal phase GnRH agonist | 1067 (9.2) | 1012 (9.3) | 32 (10.1) | 23 (6.4) | ||
| Progesterone primed ovarian stimulation | 2257 (19.5) | 1996 (18.3) | 24 (7.5) | 237 (65.8) | ||
| FSH on HCG day (mIU/mL), mean (SD) | 15.6 (5.6) | 15.5 (5.6) | 14.9 (5.7) | 18.4 (6.3) | 0.050 | <0.001 |
| LH on HCG day (mIU/mL), mean (SD) | 2.1 (2.2) | 2.1 (2.1) | 1.8 (1.9) | 3.7 (4.5) | 0.007 | <0.001 |
| E2 on HCG day (pg/mL), mean (SD) | 2790 (1850) | 2840 (1850) | 2800 (1700) | 1170 (956) | 0.700 | <0.001 |
| P on HCG day (ng/mL), mean (SD) | 1.1 (0.7) | 1.1 (0.7) | 1.0 (0.8) | 0.9 (1.0) | 0.543 | <0.001 |
| Total dose of Gn (IU), mean (SD) | 1980 (680) | 1980 (673) | 2040 (690) | 1790 (843) | 0.108 | <0.001 |
| Duration of stimulation (days),mean (SD) | 10.4 (2.6) | 10.4 (2.6) | 11.1 (2.4) | 9.0 (3.7) | <0.001 | <0.001 |
| Number of retrieved oocytes, mean (SD) | 9.8 (6.4) | 10.0 (6.4) | 11.1 (5.7) | 2.6 (2.7) | <0.001 | <0.001 |
| Pretreatment semen analysis | ||||||
| Initial sperm concentration (million/mL), mean (SD) | 74.6 (56.3) | 74.6 (56.3) | 68.6 (47.9) | 80.9 (60.3) | 0.029 | 0.053 |
| Initial normal sperm morphology, mean (SD) | 4.9 (2.8) | 4.9 (2.7) | 5.1 (3.1) | 5.6 (4.8) | 0.273 | 0.009 |
| Initial progressive sperm motility, mean (SD) | 40.8 (14.5) | 41.0 (14.4) | 37.3 (14.1) | 38.1 (14.8) | <0.001 | <0.001 |
Continuous variables are expressed as mean (SD), categorical variables as absolute frequencies, n (%).
BMI, body mass index; E2, estradiol; FSH, follicular-stimulating hormone; Gn, gonadotropin; GnRH, gonadotropin-releasing hormone; HCG, human chorionic gonadotropin; LFR, low fertilisation rate; LH, luteinising hormone; P, progesterone; TFF, total fertilisation failure.