FIGURE 7.

Cytokine regulation of NME in human AA and SS erythrocytes. Mg²⁺‐loaded AA (white bars) and SS red cells (gray bars) were subjected to measurement of NME at 37°C in the absence or presence of 100 nM platelet‐activating factor (PAF), 100 nM prostaglandin E2 (PGE2) or 40 ng/ml RANTES. (A) Na⁺‐dependent Mg²⁺ efflux. ^# p < .04 (CTL vs. each cytokine) in AA cells; *p < .04 (control vs. each cytokine in SS cells). (B) Na⁺‐independent Mg²⁺ efflux. *p = .0357 (SS + PGE2 vs. AA + PGE2). Means ± SEM of >3 triplicate determinations. Mann–Whitney test. Differences between CTL and each cytokine did not achieve significance in AA or SS red cells.