Table 5.
Secondary clinical outcomes
| Enrollment | 10 Weeks | 12 Months | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| Prism (n = 32) | Surgery (n = 76) | Prism N = 30 | Surgerya (n = 74) | Prism (n = 25) | Surgerya (n = 63) | |||||
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| Mean ± SD | Mean ± SD | Mean ± SD | Mean change from baseline (95% CI) | Mean ± SD | Mean change from baseline (95% CI) | Mean ± SD | Mean change from baseline (95% CI) | Mean ± SD | Mean change from baseline (95% CI) | |
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| DQ Scoreb | 41 ± 19 | 65 ± 21 | 12 (23) | −29 (−40 to −19) | 5 (13) | −60 (−66 to −55) | 18 (27) − | −24 (−34 to −14) | 4 ± 11 | −62 (−68 to −56) |
| AS-20 General Functionc | 64 ± 26 | 61 ± 21 | 83 (16) | 19 (10 to 28) | 90 (15) | 29 (24 to 34) | 79 (21) | 14 (5 to 23) | 92 ± 14 | 29 (24 to 35) |
| AS-20 Reading Functionc | 79 ± 21 | 67 ± 24 | 82 (23) | 3 (−5 to 10) | 87 (20) | 20 (15 to 24) | 84 (18) | 7 (−3 to 18) | 90 ± 16 | 22 (16 to 27) |
| AS-20 Self-perceptionc | 92 ± 17 | 85 ± 20 | 91 (13) | −1 (−6 to 5) | 95 (14) | 9 (5 to 12) | 94 (11) | 3 (−4 to 11) | 97 ± 7 | 11 (6 to 15) |
| AS-20 Interaction | 95 ± 10 | 94 ± 12 | 95 (10) | 0 (−4 to 3) | 97 (12) | 3 (1 to 5) | 98 (5) | 2 (−1 to 5) | 99 ± 3 | 5 (3 to 7) |
AS-20, Adult Strabismus-20 questionnaire; CI, confidence interval; DQ, Diplopia Questionnaire; SD, standard deviation.
a
Nine participants received additional treatment between the 10-week and 12-month examinations. For these participants, data collected at 10 weeks were included in the table, but data collected at 12 months were excluded from the table.
b
DQ scores range from 0 to 100, with 0 being best (no diplopia) and 100 being worst (diplopia in all gazes all the time); improvement is thus reflected as negative change.
c
AS-20 domain scores range from 0 to 100, with 0 being the worst HRQOL and 100 being the best HRQOL; improvement is thus reflected as positive change.