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. Author manuscript; available in PMC: 2022 Nov 28.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2021 Jun 15;17(8):903–921. doi: 10.1080/17425255.2021.1935867

Figure 4. Example of a generic gas inhalation PBTK model. A single (generic) physiological structure is used for all appropriate chemicals.

Figure 4.

Chemical-specific parameters can be predicted from a combination of in vitro measurements and QSARs. Qrest is defined as the difference between Qcardiac and the flow to the liver, kidney, and gut to preserve mass-balance.