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. 2022 Nov 15;30:569–584. doi: 10.1016/j.omtn.2022.11.010

Figure 1.

Figure 1

Effect of radiation and impact of pre-treatment with CDX-301 on expression of miRNAs

(A) Venn diagram shows a total number of differentially expressed miRNAs in the serum of RV group. (B) Histogram shows a total number of downregulated and upregulated miRNAs in the serum of RV and RD groups compared with the NRV control groups at different time intervals, i.e., on day 1, 4, 7, or 14 post irradiation. (C) Venn diagram shows total number of differentially expressed miRNAs in the spleen of RV group. (D) Histogram shows total number of downregulated and upregulated miRNAs in the spleen of RV and RD groups in comparison with NRV control groups at different time intervals, i.e., on day 1, 4, 7, or 14 post irradiation. (E and F) Heatmaps indicate the differential expression of miRNAs in murine (E) serum and (F) spleen of the RV and RD groups compared with the NRV control group at days 4, 7, and 14 post irradiation.