Figure 1.

Comparison of mouse and human ATM diversity during obesity. For mice, lean states are dominated by a resident ATM pool that can be divided into at least two subtypes. With diet induced obesity, lipid associated ATMs (LAM) accumulate in crown like structures (CLS) and are maintained via proliferative and recruitment mechanisms. In humans, LAM ATMs are part of the resident tissue pool along with CD206+ ATMs. With obesity and metabolic disease, CD206+ ATMs expanded in adipose tissue in contrast with mouse models of obesity. In addition, CLS are much less abundant in human adipose tissue.