Table 1.
Characteristics of subgroup (by the NanoString assay)
| Clinical Features | Number of Cases (%) or value | ||||
|---|---|---|---|---|---|
| WNT (N = 14) | SHH (N = 20) | Group 3 (N = 18) | Group 4 (N = 39) | P value | |
| Gender | 0.003 | ||||
| M | 3 (21.4%) | 11 (55.0%) | 14 (77.8%) | 28 (71.8%) | |
| F | 11 (78.6%) | 9 (45.0%) | 4 (22.2%) | 11 (28.2%) | |
| Age (years) | 0.007 | ||||
| ≤ 3 | 1 (7.1%) | 7 (35.0%) | 7 (38.9%) | 3 (7.7%) | |
| 3–18 | 13 (92.9%) | 13 (65.0%) | 11 (61.1%) | 36 (92.3%) | |
| Metastasis at diagnosis | 0.096 | ||||
| Negative | 11 (78.6%) | 14 (70.0%) | 7 (38.9%) | 25 (64.1%) | |
| Positive | 3 (21.4%) | 6 (30.0%) | 11 (61.1%) | 14 (35.9%) | |
| Tumor location | < 0.001 | ||||
| Midline | 8 (57.1%) | 8 (40.0%) | 18 (100.0%) | 39 (100.0%) | |
| Hemispheric | 0 (0.0%) | 12 (60.0%) | 0 (0.0%) | 0 (0.0%) | |
| Peduncle | 6 (42.9%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| Histology | 0.018 | ||||
| Classic | 13 (92.9%) | 5 (25.0%) | 10 (55.6%) | 27 (69.2%) | |
| MBEN | 0 (0.0%) | 5 (25.0%) | 4 (22.2%) | 5 (12.8%) | |
| DN | 1 (7.1%) | 4 (20.0%) | 1 (5.6%) | 2 (5.1%) | |
| LCA | 0 (0.0%) | 6 (30.0%) | 3 (16.7%) | 5 (12.8%) | |
Abbreviations: WNT Wingless signaling-activated, SHH Sonic-hedgehog signaling-activated, MBEN Medulloblastoma with extensive nodularity, DN Desmoplastic/nodular, LCA Large cell/anaplastic
P values were calculated using the the chi-square test for independence