Table 2.
Overview of circRNAs identified by RNA sequencing and microarrays in BC
| Sample | Subtype of BC | Detection method | Number of circRNAs | Number of differently expressed circRNAs (upregulated/ downregulated) | Fold Change | P value | Ref |
|---|---|---|---|---|---|---|---|
| 4 pairs of BC and BCN tissues | TNBC | RNA-seq | – | 354 (47/307) | ≥ 2 | < 0.05 | [42] |
| 3 pairs of BC and BCN tissues | TNBC | RNA-seq | 69815 | 5033 (1307/3726) | ≥ 2 | < 0.05 | [32] |
| 4 pairs of BC and BCN tissues | IDC | circRNA microarray | – | 1155 (715/440) | ≥ 2 | < 0.05 | [43] |
| MCF7/TR and MCF7/P cells | HR-positive BC | RNA-seq | 36110 | 465 (352/113) | > 1 | < 0.01 | [39] |
| three TNBC cell lines (MDA-MB-231, MDA-MB468 and BT549) and one HME cell line (MCF-10A) | TNBC | circRNA microarray | – | 270 (93/174) | > 3 | < 0.05 | [44] |
| 4 pairs of BC and para-cancer tissues | non-TNBC | circRNA microarray | – | 85 (63 /22) | ≥ 2 | < 0.05 | [45] |
| 5 pairs of BC and paired normal tissues | TNBC | RNA-seq | 27346 | 1200 (613/587) | ≥ 2 | < 0.01 | [46] |
| 5 pairs of plasma of BC patients and healthy controls | – | circRNA microarray | – | 41 (19/22) | ≥ 2 | < 0.05 | [43] |
| 4 pairs of BC and para-cancer tissues | TNBC | circRNA microarray | – | 250 (173/77) | ≥ 1.5 | < 0.05 | [47] |
| BC and NMGT tissues |
TNBC (4 BC, 3 NMGT) |
circRNA microarray | – | 215 (122/93) | – | – | [40] |
|
Luminal A (4BC, 3 NMGT) |
circRNA microarray | – | 73 (55/18) |
NMGT normal mammary gland tissues, BCN tissues normal breast tissues of patients with breast cancer