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Skin irritation study using Draize scoring of formalin treated and gel treated rats as compared with untreated rats
| Time (hrs) |
Untreated rat (Control) |
Formalin Treated rats |
ALP-loaded NLCs Treated rats |
|
|---|---|---|---|---|
| Erythema | 1 | 0 | 3 | 1 |
| 12 | 0 | 3 | 0 | |
| 24 | 0 | 2 | 0 | |
| Edema | 1 | 0 | 1 | 0 |
| 12 | 0 | 2 | 0 | |
| 24 | 0 | 2 | 0 | |
| PDI | 1 | 0 | 4 | 1 |
| 12 | 0 | 5 | 0 | |
| 24 | 0 | 4 | 0 | |
| PDII | 0 |
4.33 (Moderate) |
0.33 (Non-significant) |
PDI Primary dermal irritation, PDII Primary dermal irritation index
