Table 1. Selected studies at the end of the analyses.

Authors	Study design	Sampling	Intervention	Control	Primary outcome
Bone et al. (2008) 21	Case series	n = 7	PPS	−	Increased survival
Collinge et al. (2009) 17	NRCT	n = 107	Quinacrine	−	Increased survival
Geschwind et al. (2013) 18	RCT	n = 51 (I= 23, C= 28)	Quinacrine	Placebo	Increased survival
Haïk et al. (2004) 19	Case series	n = 32	Quinacrine	−	Increased survival
Haïk et al. (2014) 23	RCT	n = 121 (I= 62, C= 59)	Doxycycline	Placebo	Increased survival
Nakajima et al. (2004) 20	NCI	n = 4	Quinacrine	−	Increased survival
Otto et al. (2004) 25	RCT	n = 28 (I= 13, C= 15)	Flupirtine	Placebo	Cognitive decline reduction
Tsuboi et al. (2009) 22	NCI	n = 11	PPS	−	Increased survival
Varges et al. (2017) 24	RCT*	n = 13 (I= 7, C= 6)	Doxycycline	Placebo	Increased survival
Varges et al. (2017) 24	NRCT*	n = 88 (I= 55, C= 33)	Doxycycline	−	Increased survival

Abbreviations: C, control group; I, intervention group; NCI, non-controlled intervention; NRCT, non-randomized clinical trial; PPS, pentosan polysulfate; RCT, randomized clinical trial.

Notes: *The study by Varges et al. ²⁴ was composed of 2 groups, one as RCT and the other as NRCT.