Table 2.
Candidate variants from the main and subtype analysis
| snpid | rsid | A1 | A2 | FRQ | OR | OR_95L | OR_95U | PPR | P | gene | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Main analysis | chr3:45848457:C:T | rs35731912 | T | C | 0.09 | 1.784 | 1.723 | 1.847 | 1.000 | 2.32E−21 | LZTFL1 |
| chr19:10351837:C:T | rs11085725 | T | C | 0.273 | 1.269 | 1.254 | 1.283 | 1.000 | 1.02E−10 | TYK2 | |
| chr9:133261703:A:G | rs687289 | A | G | 0.358 | 1.240 | 1.219 | 1.262 | 1.000 | 4.49E−10 | ABO | |
| chr19:4717660:A:G | rs12610495 | G | A | 0.27 | 1.216 | 1.188 | 1.244 | 0.990 | 9.91E−08 | DPP9 | |
| chr9:14754866:A:G | rs7023573 | A | G | 0.285 | 1.207 | 1.185 | 1.231 | 0.954 | 5.21E−07 | FREM1 | |
| chr17:45933112:G:A | rs8065800 | G | A | 0.328 | 1.194 | 1.145 | 1.247 | 0.925 | 8.90E−07 | MAPT | |
| chr4:30946048:T:C | rs12512667 | C | T | 0.444 | 0.850 | 0.828 | 0.873 | 0.922 | 8.95E−07 | PCDH7 | |
| Subtype analysis | chr19:10351837:C:T | rs11085725 | T | C | 0.272 | 1.309 | 1.294 | 1.325 | 0.999 | 3.24E−09 | TYK2 |
| chr19:4717660:A:G | rs12610495 | G | A | 0.267 | 1.286 | 1.257 | 1.316 | 0.993 | 2.87E−08 | DPP9 | |
| chr13:55031860:T:C | rs111671068 | C | T | 0.012 | 2.802 | 2.794 | 2.810 | 0.806 | 1.43E−07 | OLFM4 | |
| chr9:133271182:T:C | rs550057 | T | C | 0.266 | 1.262 | 1.238 | 1.286 | 0.939 | 4.56E−07 | ABO | |
| chr18:7897309:A:C | rs17565758 | C | A | 0.078 | 1.510 | 1.470 | 1.550 | 0.938 | 4.84E−07 | PTPRM | |
| chr21:33247902:C:T | rs2834161 | C | T | 0.371 | 1.250 | 1.175 | 1.331 | 0.923 | 6.10E−07 | IFNAR2 |
We show only variants that have a PPR > 0.8 in the MAMBA analysis. A more detailed overview of all variants is shown in Supplementary Material, Table S3. snpid: id of the marker as chr:pos:alleles, genome build hg38; A1: minor allele from TopMed imputation; A2: major allele from TopMed imputation; OR/OR_95L/OR_95U: OR and 95% CI of A1; PPR: posterior probability of replication; P: P value of association.