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. Author manuscript; available in PMC: 2022 Nov 28.
Published in final edited form as: Methods Enzymol. 2018 Feb 21;601:111–144. doi: 10.1016/bs.mie.2017.11.028

Table 3.

Pearson Correlation Coefficients for Pairwise Comparison of NGS Alignment Softwares

Aligner Pairs No Processing
Window Correction
8 bp Processing
Window Correction
Geneious & CLC 0.9981 0.9995
Geneious & Bowtie2 0.9985 0.9999
Geneious & BWA 0.9986 1
CLC & Bowtie2 0.9994 0.9996
CLC & BWA 0.9994 0.9995
Bowtie2 & BWA 0.9994 0.9999

After processing window adjustment, all aligners become more similar to each other. However, Geneious and BWA remain the most similar.