Table 2.
Reaction condition optimization of the cycloisomerization of alkynyl ketone 9.
| ||||
|
| ||||
| entry | acid | solvent | T (°C) | yield (%) |
|
| ||||
| 1 | TsOH | DCM | 23 | 0 |
| 2 | TsOH | DCM | 40 | 0 |
| 3 | TsOH | DCE | 70 | 73 |
| 4 | TFA | DCE | 70 | 50 |
| 5 | AcOH | DCE | 70 | 24 |
| 6 | PhCO2H | DCE | 70 | 39 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.