TABLE 2.

Mean K_D value by variant

Variant	Mean KD value (M [95% CI]) fora:
	Tixagevimab	Cilgavimab
D614G	7.57E−10 (5.4E−10, 1.1E−9)	<1E−12 (NE)
Wild-type	4.91E−10 (3.4E−10, 6.9E−10)	<1E−12 (NE)
S494L:D614G	8.55E−10 (6.0E−10, 1.2E−9)	1.59E−8 (1.1E−8, 2.2E−8)
K444R:D614G	5.37E−10 (3.8E−10, 7.5E−10)	NA (NE)
F486S:D614G	NB (NE)	<1E−12 (NE)
F486W:D614G	NA (NE)	<1E−12 (NE)

^aK_D, equilibrium dissociation constant; M, mol/L; CI, confidence interval; NE, 95% CI was not evaluable; NA, not available due to poor binding with inaccurate curve fitting; NB, no binding. 1E−12 M was used for K_D values of <1E−12 M, and 95% CI was not calculated for variants with a mean K_D of <1E−12 M.